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目的:探讨新生儿换血疗法对救治血型不合引起新生儿溶血病(HDN)的疗效。方法:对确诊的13例HDN患儿,采用成份血换血治疗,配血量约是患儿血容量的2倍,换血速度为180ml/h,换血出入量差不能大于20ml。换血前后进行血常规,胆红素,肾功能监测。结果:换血前血色素109±10.1,红细胞压积34.2±6.3;换血后血色素143.8±12,红细胞压积43.8±3.9;换血前总胆红素429.86±61.27,直接胆红素31.78±13.21,间接胆红素401.21±59.31;换血后总胆红素198.57±29.31,直接胆红素24.91±19.72,间接胆红素172.1±42.13差异均有统计学意义(P<0.05)。肾功能无显著性改变。结论:选用成份血换血治疗方便,疗效显著。
Objective: To investigate the effect of neonatal blood transfusion therapy on the treatment of neonatal hemolytic disease (HDN) caused by blood group incompatibility. Methods: Thirteen patients diagnosed with HDN were treated with blood transfusions. The blood volume was about twice that of children with blood transfusions of 180ml / h, and the difference of transfusion volume was no more than 20ml. Blood before and after the exchange of blood, bilirubin, renal function monitoring. Results: The hemoglobin before transfer was 109 ± 10.1 and the hematocrit was 34.2 ± 6.3. The hemoglobin after transfusion was 143.8 ± 12 and the hematocrit was 43.8 ± 3.9. The total bilirubin before transfusion was 429.86 ± 61.27, the direct bilirubin was 31.78 ± 13.21, 401.21 ± 59.31, total bilirubin 198.57 ± 29.31, direct bilirubin 24.91 ± 19.72, and indirect bilirubin 172.1 ± 42.13 (P <0.05). No significant changes in renal function. Conclusion: The selection of blood transfusion for the convenience of treatment, significant effect.