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目的 探讨雌、孕激素受体 (ER、PR)状态不同的乳腺癌是否在发病危险因素方面有差异。方法 1996年 3月～ 1998年 1月间在大连医科大学附属一、二院进行了一次病例对照研究。结果 病例间受体状态分析提示在年龄上 ER组间有差别 ;PR组间各因素都没有差异。病例对照间单因素及多因素L ogistic回归分析发现按 ER状态分层 ,唯有 BMI、活产胎数、哺乳时间对 ER(+)及 ER(- )乳腺癌危险性的作用不同 ;按 PR状态分层分析各因素对 PR(+)及 PR(- )乳腺癌的作用是一致的。结论 结果从总体上支持 Moolgavkar等人的两阶段模型假说
Objective To investigate whether breast cancers with different status of estrogen and progesterone receptors (ER, PR) have different risk factors. Methods A case-control study was conducted in the First and Second Affiliated Hospitals of Dalian Medical University from March 1996 to January 1998. RESULTS: The analysis of receptor status among cases suggested that there was a difference between the ER groups in age; there was no difference among the PR groups. Univariate and multivariate logistic regression analysis between case controls revealed that stratified by ER status, only BMI, number of live births, and breastfeeding time had different effects on ER(+) and ER(-) breast cancer risk; according to PR The stratified state analysis of the factors was consistent with PR(+) and PR(-) breast cancer. Conclusion The results generally support the two-stage model hypothesis of Moolgavkar et al.