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从超微结构水平，研究早孕妇女口服米非司酮（２５ｍｇ，Ｂｉｄ×２天）４８ｈ后，蜕膜和绒毛的超微结构改变，结果表明：蜕膜中大蜕膜细胞皱缩，粗面内质网和线粒体肿胀，蜕膜颗粒细胞中高电子密度颗粒减少或消失，同时伴随着周围网状纤维的溶解；而绒毛功能活跃的合体滋养细胞则表现不同程度的退行性改变。表明米非司酮阻断孕激素作用，对蜕膜的影响是直接的，而绒毛则主要是受继发性血供不足的影响。蜕膜中颗粒细胞及基质中网状纤维是米非司酮抗早孕重要的作用部位。
From the level of ultrastructure, the ultrastructural changes of decidua and chorion were observed after oral administration of mifepristone (25 mg, Bid × 2 days) for 48 h in early pregnant women. The results showed that the large decidual cells in decidua shrink, Endoplasmic reticulum and mitochondria swelling, decidua granulosa cells with high electron density particles reduce or disappear, accompanied by the dissolution of the surrounding reticular fibers; and villi function of the active syncytiotrophoblast showed varying degrees of degenerative changes. Show mifepristone progesterone blocking effect on the decidua is direct, while the villus is mainly affected by the secondary blood supply deficiencies. Decidua in the granulosa cells and matrix reticular fibers is an important part of anti-pregnancy of mifepristone role.