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目的:探讨妊娠糖尿病患者(GDM)空腹抵抗素水平与胰岛素抵抗(IR)的关系。方法:检测54例GDM者和50例正常血糖(NBG)孕妇的血清空腹抵抗素水平,同时以稳态模型HOMA-IR计算胰岛素抵抗指数。结果:GDM组抵抗素水平和HOMA-IR指数高于NBG组,差异具有统计学意义(P<0.05);GDM组多元线性逐步回归分析结果显示,孕前体质指数(BMI)和腹围(WC)、孕期抵抗素是IR的独立危险因素。结论:GDM者血清抵抗素水平高于NBG者,抵抗素升高与IR密切相关。
Objective: To investigate the relationship between fasting resistin and insulin resistance (IR) in gestational diabetes mellitus (GDM). Methods: Serum fasting resistin levels were measured in 54 GDM patients and 50 normal glucose (NBG) pregnant women, and insulin resistance index was calculated by steady-state model HOMA-IR. Results: The levels of resistin and HOMA-IR index in GDM group were higher than those in NBG group (P <0.05). The results of multiple linear stepwise regression analysis in GDM group showed that body mass index (BMI) and abdominal circumference (WC) , Resistin during pregnancy is an independent risk factor for IR. Conclusion: The level of serum resistin in GDM is higher than that in NBG. The increase of resistin is closely related to IR.