本文对棉酚影响短期培养的人外周血淋巴细胞染色体数目、畸变和姊妹染色单体交换频率(SCE)的效应进行了分析。初步结果如下:①服药组与对照组的中期染色体结构畸变出现率,未见明显差异。②高浓度棉酚(9微克)组计数112个中期细胞中有10个多倍体(占9％),与对照组多倍体出现率(12/351)比较,有统计学差异。③在棉酚对SCE的效应 In this paper, the effects of gossypol on chromosome number, aberration and sister chromatid exchange frequency (SCE) of peripheral blood lymphocytes in short-term culture were analyzed. The preliminary results are as follows: ① There was no significant difference in the incidence of mid-term chromosomal structural aberrations between the medication group and the control group. (2) High concentration gossypol (9 microgram) group had 10 polyploidy (9%) in 112 metaphase cells, which was significantly different from that of control group (12/351). ③ gossypol on SCE effect