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为了探讨能快速评价预防型抗氟剂效果的实用指标，给大鼠短期饮用高氟水（５０ｍ ｇ／Ｌ）染毒，观察氟对骨相与非骨相指标的影响。染毒１周后实验组大鼠尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）活力、全血胆碱酯酶（ＣｈＥ）活力及尿氟含量即显著高于对照组（Ｐ＜ ０．０１）；以后３周升高的幅度不明显，但仍保持较高水平。尿羟脯氨酸、血清羟脯氨酸含量实验前后两组间未见显著差异，４周后实验组骨和牙氟含量比对照组高十几倍。本文结果表明评价预防型抗氟剂效果除必须以骨、牙氟含量为关键指标外，尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶和全血胆碱酯酶活力也可作为参考
In order to explore the practical indicators that can quickly evaluate the effect of prophylactic antifluoride, the rats were exposed to high fluoride water (50m g / L) for a short period of time to observe the effect of fluoride on the phase of bone and non-bone. One week after exposure, the activity of NAG, ChE and urinary fluoride in the experimental group were significantly higher than those in the control group (P < 0.01). The amplitude of increase after 3 weeks was not obvious, but still maintained a high level. Urine hydroxyproline, serum hydroxyproline content before and after the experiment no significant difference between the two groups, 4 weeks after the experimental group bone and tooth fluoride content ten times higher than the control group. The results of this paper show that in addition to the need to evaluate the effect of prophylactic anti-fluoride bone, tooth fluoride content as a key indicator, urine N-acetyl-β-D-glucosaminidase and whole blood cholinesterase activity can also be used as a reference