胆囊原发性恶性黑色素瘤是一种高度恶性肿瘤,并且极为罕见。查阅国内外文献[1-10],记载的仅有29例。因其组织起源尚不明确,并且易误诊为、急慢性胆囊炎、胆囊结石、胆囊息肉等。本文报道1例术前以“胆囊结石伴胆囊炎”收住院,经腹腔镜胆囊切除术后,诊断为“胆囊原发性恶性黑色素瘤”的病例,并结合文献复习探讨其临床病理特征、诊断、鉴别诊断和预后。 Gallbladder primary malignant melanoma is a highly malignant tumor and is extremely rare. Access to domestic and foreign literature [1-10], documented only 29 cases. Because of its organizational origin is not clear, and easily misdiagnosed as acute and chronic cholecystitis, gallstones, gallbladder polyps. This article reports a case of preoperative “gallbladder stones with cholecystitis,” admitted to hospital, after laparoscopic cholecystectomy, the diagnosis of “gallbladder primary malignant melanoma,” the case, combined with the literature review of its clinical Pathological features, diagnosis, differential diagnosis and prognosis.