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目的探讨吡格列酮、依那普利治疗2型糖尿病合并高尿酸血症的疗效。方法新郑市人民医院自2011年1月至2013年1月收治的2型糖尿病患者112例,按照随机数字表法分为两组,其中对照组54例,给予吡格列酮治疗;治疗组58例,给予吡格列酮联合依那普利治疗。比较两组患者空腹血糖(FPG)、血清总胆固醇(TC)、血清三酰甘油(TG)、餐后2 h血糖(2 h PG)、24 h尿蛋白排泄率(24 h UPE)、血尿酸(UA)及血压变化。结果两组FPG、TC、TG、2 h PG、24 h UPE、UA水平及血压治疗后较同组治疗前降低(P<0.05),治疗后治疗组与对照组FPG、TC、TG、2 h PG、24 h UPE、UA水平及血压比较均降低(P<0.05)。结论吡格列酮、依那普利治疗2型糖尿病合并高尿酸血症,疗效确切,值得临床推广应用。
Objective To investigate the efficacy of pioglitazone and enalapril in the treatment of type 2 diabetes with hyperuricemia. Methods One hundred and twelve patients with type 2 diabetes who were admitted to Xinzheng City People’s Hospital from January 2011 to January 2013 were divided into two groups according to the random number table. Among them, 54 patients in the control group received pioglitazone treatment; 58 patients in the treatment group received Pioglitazone combined with enalapril treatment. The levels of fasting blood glucose (FPG), serum total cholesterol (TC), serum triglyceride (TG), 2 h postprandial blood glucose (2 h PG), 24 h urinary protein excretion (24 h UPE) (UA) and blood pressure changes. Results The levels of FPG, TC, TG, 2 h PG, 24 h UPE, UA and blood pressure in the two groups were significantly lower than those before treatment (P <0.05) PG, 24 h UPE, UA levels and blood pressure were lower (P <0.05). Conclusion Pioglitazone and enalapril treatment of type 2 diabetes combined with hyperuricemia, curative effect is exact, worthy of clinical promotion and application.