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心房颤动是临床上最常见的快速性心律失常之一，目前中国约有800万心房颤动患者，随着社会人口老龄化，心房颤动的发病率逐渐上升。其严重并发症包括脑栓塞、脑卒中等，而脑卒中也是心房颤动致死的重要因素。近年来心房颤动发病机制取得了重要的进展，从基因、离子通道等方面对心房颤动的理解得到了充分的更新。应用新的遗传学研究方法以揭示基因突变导致部分家族性心房颤动的机制，这些有助于理解心房颤动的分子机制及所导致的电生理改变，亦有助于提供新的诊疗观点，现将家族性心房颤动近期遗传分子学研究进展予以综述。“,”Atrial fibrillation is one of the most common clinical arrhythmia ,and there are about 8 million atrial fibrillation patients in China at present .The incidence of atrial fibrillation gradually increased with the aging population .Its severe complications include cerebral embolism,stroke,etc.,and stroke is also an important factor in death caused by atrial fibrillation .In recent years,the pathogenesis of atrial fi-brillation has made important progress ,and the understanding of atrial fibrillation has been fully updated from the genes and ion channels .The use of new genetic approaches to reveal the mechanism of gene mutation in some familial atrial fibrillation can help to understand the molecu -lar mechanisms of atrial fibrillation and the resulting electrophysiological changes ,and to provide new insights .The following is a review of fa-milial atrial fibrillation genetic and molecular research progress .