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目的:研究贞芪扶正分散片对肿瘤放疗的增效和减毒作用。方法:采用移植性艾氏腹水瘤和S180肉瘤小鼠,对照组X线照射,联合用药组ig贞芪扶正分散片同时X线照射。增效试验于末次给药后观察动物死亡情况,计算生命延长率;末次给药24h后动物称体重,处死后剥离瘤块,计算肿瘤生长抑瘤率。减毒试验于末次给药后采血,检测红细胞、白细胞和血小板数。结果:贞芪扶正分散片和X线照射联合应用时,对上述两种肿瘤均有不同程度的抑瘤增效作用;对X线所致艾氏腹水瘤小鼠和S180肉瘤小鼠的红细胞、白细胞、血小板数异常均有一定的改善作用。结论:贞芪扶正分散片对移植性艾氏腹水瘤小鼠和S180肉瘤小鼠的放疗具有增效和减毒的双重作用。
Objective: To study the synergistic and attenuated effects of Zhenqi Fuzheng Dispersible Tablets on tumor radiotherapy. Methods: Transplanted Ehrlich ascites tumor and S180 sarcoma mice, the control group X-ray irradiation, the combination group ig Zhenqi Fuzheng dispersible tablets at the same time X-ray irradiation. After the last administration, the animals were sacrificed and the animals were sacrificed after the last administration. The animals were weighed after 24 hours after the last administration, and the tumor pieces were peeled off after sacrifice to calculate the tumor growth inhibition rate. Attenuation test Blood samples were taken after the last dose, and the number of erythrocytes, leukocytes and platelets was measured. Results: Combined application of Zhenqi Fuzheng Dispersible Tablets and X-ray irradiation, the two kinds of tumors both had antitumor and synergistic effects to varying degrees. To the erythrocytes of Ehrlich ascites tumor and S180 sarcoma mice induced by X- Leukocyte, platelet abnormalities have some improvement. Conclusion: Zhenqi Fuzheng Dispersible Tablet has dual effects of synergistic and attenuated radiotherapy on transplanted Ehrlich ascites tumor mice and S180 sarcoma mice.
