论文部分内容阅读
目的探讨孕妇外阴阴道假丝酵母菌病(VVC)与糖代谢异常程度的关系。方法选择2004年1月至2005年6月在北京大学第一医院产科行产前检查并分娩的401例妊娠期糖代谢异常孕妇为观察对象,其中妊娠期糖尿病244例,妊娠期糖耐量受损157例。401例中,51例孕期合并VVC(VVC 组),其中16例孕期曾有 VVC 再次发作(反复 VVC 组);350例未合并 VVC(NVVC 组)。比较3组孕妇的50 g 葡萄糖筛查试验(GCT)、75 g 葡萄糖耐量试验(OGTT)结果。结果妊娠期糖尿病患者 VVC 的发病率(16%,39/244)高于妊娠期糖耐量受损(7.6%,12/157)者,两者比较,差异有统计学意义(P=0.014);VVC 组及 NVVC 组 GCT 分别为(9.6±2.0)、(9.3±1.6)mmol/L;OGTT 空腹血糖分别为(5.4±1.1)、(5.3±0.9)mmol/L;1 h 血糖分别为(11.1±1.7)、(11.0±1.5)mmol/L;2 h血糖分别为(9.4±1.8)、(9.2±1.6)mmol/L;分别比较,差异均无统计学意义(P>0.05)。反复 VVC组 GCT 为(10.4±1.2)mmol/L;OGTT 空腹、1、2 h 血糖分别为(5.3±0.6)mmol/L、(11.4±1.0)mmol/L 和(9.4±1.4)mmol/L 与 NVVC 组比较,差异均无统计学意义(P>0.05)。结论妊娠合并糖代谢异常伴 VVC 时,GCT、OGTT 各点血糖水平无显著升高,但妊娠期糖尿病与妊娠期糖耐量受损孕妇比较,VVC 发病率呈现上升趋势。
Objective To investigate the relationship between vulvovaginal candidiasis (VVC) and abnormal glucose metabolism in pregnant women. Methods From January 2004 to June 2005, 401 pregnant women with gestational diabetes mellitus with abnormal glucose metabolism during prenatal examination and delivery in the obstetrical department of Peking University First Hospital were enrolled. Among them, 244 cases of gestational diabetes mellitus were impaired in gestational glucose tolerance 157 cases. Of the 401 patients, 51 had VVC during pregnancy (VVC group), of whom 16 had recurrent VVC during pregnancy (repeated VVC group) and 350 had no VVC (NVVC group). 50 g glucose screening test (GCT), 75 g glucose tolerance test (OGTT) results were compared among the three groups of pregnant women. Results The incidence of VVC in gestational diabetes mellitus was higher than that in gestational diabetes mellitus (16%, 39/244), which was significantly lower than that in gestational diabetes mellitus (7.6%, 12/157). There was a significant difference between the two groups (P = 0.014). The GCT of VVC group and NVVC group were (9.6 ± 2.0) and (9.3 ± 1.6) mmol / L, respectively. The fasting blood glucose of OGTT was (5.4 ± 1.1) and (5.3 ± 0.9) mmol / ± 1.7) and (11.0 ± 1.5) mmol / L, respectively. The blood glucose levels at 2 h were (9.4 ± 1.8) and (9.2 ± 1.6) mmol / L, respectively. There was no significant difference between the two groups (P> 0.05). The GCT of repeated VVC group was (10.4 ± 1.2) mmol / L, the fasting blood glucose and serum 1,2, and 2 h glucose levels were (5.3 ± 0.6) mmol / L, (11.4 ± 1.0) mmol / Compared with NVVC group, the difference was not statistically significant (P> 0.05). Conclusions There is no significant increase in the blood sugar level of GCT and OGTT in pregnant women with abnormal glucose metabolism and VVC. However, the incidence of VVC in pregnant women with gestational diabetes mellitus is significantly higher than that in pregnant women with impaired glucose tolerance.