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糖尿病是冠心病的等危症,糖尿病致冠状动脉粥样硬化机制复杂,初始原因为长期的血糖浓度升高,高血糖可通过短期反复的细胞内外信号通路活性及代谢的改变而导致内皮细胞的持久损伤,从而促进动脉粥样硬化的发生。研究显示,在高血糖致内皮细胞损伤进而导致动脉粥样硬化的具体机制中,慢性炎症和氧化应激程度增加被认为是最主要的病理生理因素和各种机制的共同通路。近年来研究发现,血红蛋白清道夫受体(CD163)具有明显的抗炎和抗脂质过氧化作用,在糖尿病致冠状动脉粥样硬化的防御体系中起重要作用。
Diabetes mellitus is an embolism of coronary heart disease. The mechanism of coronary atherosclerosis caused by diabetes is complex. The initial reason is the long-term increase of blood glucose concentration. Hyperglycemia can result in short-term repeated intracellular and extracellular signaling pathways and metabolic changes leading to endothelial cell Lasting damage, thereby promoting the occurrence of atherosclerosis. Studies have shown that in the mechanism of hyperglycemia caused by endothelial cell injury leading to atherosclerosis, chronic inflammation and increased oxidative stress are considered to be the most common pathophysiological factors and common mechanisms of various mechanisms. Recent studies have found that the hemoglobin scavenger receptor (CD163) has obvious anti-inflammatory and anti-lipid peroxidation and plays an important role in the defense system of coronary atherosclerosis caused by diabetes.