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心肌营养素-1是白介素-6家族的细胞因子。它可促使心肌成纤维细胞增殖和分泌胶原,同时使心肌细胞肥大,在缺血性心脏病、高血压和心力衰竭等疾病引起的心室重塑中起着重要作用。本文就心肌营养素-1在心室重塑中的作用作一综述。
Cardiotrophin-1 is an interleukin-6 family cytokine. It can promote myocardial fibroblasts to proliferate and secrete collagen, meanwhile to make cardiomyocytes hypertrophy and play an important role in ventricular remodeling caused by diseases such as ischemic heart disease, hypertension and heart failure. This article reviews the role of cardiotrophin-1 in ventricular remodeling.