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目的 探索小儿脑瘫的危险因素。方法 以医院为基础 ,采用 1∶2配比病例对照研究 ,通过询问研究对象的母亲获得有关暴露因素史 ,数据处理采用条件Logistic回归分析。 结果 单因素分析提示既往不良产史 (OR =3 2 66,P <0 0 0 5)、早产 (OR =4 793,P <0 0 0 5)、双胎妊娠 (OR =10 0 0 0 ,P <0 0 0 5)、出生体重 <2 50 0 g (OR =14 0 69,P <0 0 0 5)、延迟哭≥ 5min(OR =16 0 0 0 ,P <0 0 0 5)、妊娠间隔时间≤ 12月 (OR =2 4 2 8,P <0 0 5)、孕后 3月阴道流血 (OR =12 0 0 0 ,P <0 0 5)及黄疸(OR =3 2 0 0 ,P <0 0 5)与小儿脑瘫的发生有关联。经多因素分析 ,结果进入模型的有妊娠间隔时间短、孕后 3月阴道流血、低出生体重、双胎妊娠、延迟哭及黄疸。结论 脑瘫的发生可能是多因素作用的结果 ,妊娠间隔时间短、孕后 3月阴道出血、低出生体重、双胎妊娠、延迟哭和黄疸可能是儿童脑瘫的重要危险因素 ,尚待进一步的研究。
Objective To explore the risk factors of cerebral palsy in children. Methods Based on the hospital, a case-control study of 1: 2 ratio was conducted. The history of exposure factors was obtained by interrogating the mother of the study subjects. The data processing was conducted by conditional Logistic regression analysis. Results Univariate analysis showed that the incidence of previous pregnancy (OR = 3 2 66, P 0 05), preterm birth (OR 4 793, P 0 100), twin pregnancy (OR 10 000, Birth weight <2 50 0 g (OR = 14 0 69, P 0 05), delayed crying ≥ 5 minutes (OR 16 0 0 0, P 0 05) Intercourse time was less than 12 months (OR = 224.8, P <0.05), vaginal bleeding at 3 months after pregnancy (OR = 1200, P <0 05) and jaundice (OR = 3200 , P <0 05) was associated with the occurrence of cerebral palsy in children. After multivariate analysis, the results of the model into the short pregnancy interval, vaginal bleeding in March after pregnancy, low birth weight, twin pregnancy, delayed crying and jaundice. Conclusion The occurrence of cerebral palsy may be the result of multiple factors. Short pregnancy interval, vaginal bleeding in 3 months after pregnancy, low birth weight, twin pregnancy, delayed crying and jaundice may be important risk factors for children with cerebral palsy. For further study .