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目的通过检测原癌基因ckit蛋白(CD117)在胃肠道间质瘤(GISTs)中的表达,探讨CD117在GISTs诊断中的意义。方法收集50例GISTs病例行常规检查及免疫组化染色。标记抗体主要为CD117、CD34SMA、S100、desmin。结果50例中49例(98%)CD117阳性,39例(78%)CD34阳性,4例(8%)SMA阳性,2例(4%)S100阳性。其中良性组CD11712例(12/12)均阳性,交界性组CD1177例(7/8)阳性。恶性组30例(30/30)CD117阳性。对照组平滑肌瘤及神经鞘瘤CD117均阴性。结论CD117在GISIs的鉴别诊断中具有重要意义。
Objective To investigate the significance of CD117 in the diagnosis of GISTs by detecting the expression of the oncogene ckit protein (CD117) in gastrointestinal stromal tumors (GISTs). Methods Fifty cases of GISTs were collected routinely and immunohistochemically. The main labeled antibodies were CD117, CD34SMA, S100, desmin. RESULTS: Of the 50 patients, 49 (98%) had CD117 positive, 39 (78%) had CD34 positive, 4 (8%) had SMA positive and 2 (4%) had S100 positive. The benign group of CD11712 cases (12/12) were positive, the borderline group of CD1177 cases (7/8) were positive. Malignant group of 30 cases (30/30) CD117 positive. The control group leiomyoma and schwannoma CD117 were negative. Conclusion CD117 is of great significance in the differential diagnosis of GISIs.