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日本协和发酵公司研制成功一种对尿道感染疗效很高的药物Bacmecillinam(KW-1100BMPC)。BMPC比以前的Pibumecillinam(PMPC)在肠道吸收更好。其化学结构(图1)是在mecillinam(MPC)3位上有乙氧羰基氧酸酯基的前药,在体内被肠道酯酶作用后转变成MPC而起作用。 BMPC化学名为:1-乙氧羰基乙氧基-6β[(六
Japan’s Concorde fermentation company successfully developed a highly effective drug for urinary tract infections Bacmecillinam (KW-1100BMPC). BMPC is better absorbed in the gut than previous Pibumecillinam (PMPC). Its chemical structure (Figure 1) is a prodrug with ethoxycarbonyloxyacid group at the 3 position of mecillinam (MPC) and is converted to MPC by the action of intestinal esterase in vivo. BMPC chemical name: 1-ethoxycarbonyl ethoxy-6β [(six