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目的探讨超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及脂蛋白a[LP(a)]与急性脑梗死的关系。方法检测68例脑梗死患者(急性脑梗死组)和100例健康人(健康对照组)血清超敏C反应蛋白、同型半胱氨酸及脂蛋白a的含量。结果急性脑梗死组超敏C反应蛋白、同型半胱氨酸、脂蛋白a含量[(11.28±5.17)mg/g、(19.1±4.7)μmol/L、(468±147)mg/g]明显高于健康对照组[(2.31±1.15)mg/g、(8.32±2.1)μmol/L、(196±81)mg/g](P<0.01)。结论超敏C反应蛋白、同型半胱氨酸、脂蛋白a与急性脑梗死的发生有关,三者同时检测对急性脑梗死的早期诊断疗效观察,预后判断具有重要的临床意义。
Objective To investigate the relationship between hs-CRP, homocysteine (Hcy) and lipoprotein a [LP (a)] and acute cerebral infarction. Methods Serum high sensitivity C-reactive protein, homocysteine and lipoprotein-a were detected in 68 patients with cerebral infarction (acute cerebral infarction group) and 100 healthy people (healthy control group). Results The levels of hypersensitive C-reactive protein, homocysteine and lipoprotein in acute cerebral infarction group were significantly higher than those in control group [(11.28 ± 5.17) mg / g, (19.1 ± 4.7) μmol / L, (2.31 ± 1.15) mg / g, (8.32 ± 2.1) μmol / L, (196 ± 81) mg / g], respectively (P <0.01). Conclusions High-sensitivity C-reactive protein, homocysteine and lipoprotein a are involved in the pathogenesis of acute cerebral infarction. Simultaneous detection of the three drugs has important clinical significance in the early diagnosis and prognosis of acute cerebral infarction.