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目的探讨胃肠激素（ＧＩＨ）在肝硬变胃粘膜病变发病机制中的意义．方法用ＲＩＡ法测定临床诊断为肝硬变伴胃粘膜病变（ＣＧＭＬ）１７例，肝硬变（ＬＣ）３２例，胃溃疡（ＧＵ）１０例，轻度浅表性胃炎（ＣＳＧ）２３例及正常对照者３６例的空腹血浆生长抑素（ＳＳ），血管活性肠肽（ＶＩＰ），胃动素（ＭＴＬ）及促胃液素（Ｇａｓ）的变化，并结合各疾病组的内镜特点，分析ＣＧＭＬ与某些ＧＩＨ的关系．结果血浆ＳＳ水平（ｎｇ／Ｌ）在ＣＧＭＬ及ＧＵ组分别为４１２±２１２及３７６±１４３，与正常对照组（６１２±１７０）、ＬＣ组（６６２±３０９），ＣＳＧ组（６４８±３９１）比较，Ｐ均＜００１；ＶＩＰ浓度（ｎｇ／Ｌ）则在ＣＧＭＬ组（６３４±３５８）、ＧＵ组（１１０９±４２４）、ＬＣ组（７７８±４２６）及ＣＳＧ组（６３４±３４７）均高于正常对照组（３２７±１４４），Ｐ均＜００１．ＣＧＭＬ，ＧＵ及ＣＳＧ具不同的内镜特点；ＣＧＭＬ的发病与食管静脉曲张（ＥＶ）关系密切，随ＥＶ程度的加重，发病率有增高的趋势．结论ＣＧＭＬ发病与门脉高压关系密切，激素代谢紊乱可能通过影响内脏血流及粘膜抗损害能力而参与其形成．
Objective To investigate the significance of gastrointestinal hormone (GIH) in the pathogenesis of gastric mucosal lesions of liver cirrhosis. Methods 17 cases of cirrhosis with gastric mucosal lesions (CGML), 32 cases of liver cirrhosis (LC), 10 cases of gastric ulcer (GU), 23 cases of mild superficial gastritis (CSG) The changes of fasting plasma somatostatin (SS), vasoactive intestinal peptide (VIP), motilin (MTL) and gastrin in 36 healthy volunteers were analyzed. According to the endoscopic features of each disease group, CGML and some of the relationship between GIH. Results The levels of plasma SS (ng / L) in CGML and GU groups were 412 ± 212 and 376 ± 143 respectively, which were significantly lower than those in normal control group (612 ± 170), LC group 2 ± 309), CSG group (648 ± 391), both P <001; VIP concentration (ng / L) in CGML group (634 ± 358), GU Group (1109 ± 424), LC group (778 ± 426) and CSG group (634 ± 347) were higher than the normal control group (327 ± 144) P <001. CGML, GU and CSG have different characteristics of endoscopy. The incidence of CGML is closely related to esophageal varices (EV), and with the increasing of EV, the incidence tends to increase. Conclusions The incidence of CGML is closely related to portal hypertension. Hormonal metabolic disturbance may be involved in the formation of CGML by influencing visceral blood flow and mucosal anti-damage ability.