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目的 :探讨既往前列腺疾患对前列腺癌发病的影响。方法 :于 1997～ 1999年间对济南五大医院中经病理组织学确诊的 96例前列腺癌新发病例实施 1∶ 3配比的病例 -对照研究。三类对照共计 2 88例 (其中医院癌对照、医院非癌对照、正常对照各 96例 )。配比条件为同性别、同民族、年龄相近 (相差不超过± 5岁 )。结果 :经条件 L ogistic回归分析 ,结果显示 :前列腺癌病例与三类对照比较 ,既往前列腺疾患 (前列腺炎及前列腺良性增生 )可能增加患前列腺癌的危险性 ,两种疾患在三类对照中的 OR值分别为 7.82、9.83、7.0 0及 6 .71、7.0 0、8.42 ,P值均小于 0 .0 0 1。结论 :提示既往前列腺疾患可能是前列腺癌发病的危险因素
Objective: To investigate the effect of past prostate diseases on the incidence of prostate cancer. Methods: A case-control study was conducted in 96 new cases of prostate cancer diagnosed by histopathology in five major hospitals in Jinan from 1997 to 1999. A total of 2 88 cases of three types of control (including hospital cancer control, non-cancer hospital control, 96 cases of normal control). Matching conditions for the same sex, with ethnicity, similar age (a difference of not more than ± 5 years old). Results: By conditional L ogistic regression analysis, the results showed that compared with the three types of control, prostate cancer (prostatic hyperplasia and benign prostatic hyperplasia) may increase the risk of prostate cancer. The two diseases in three types of control OR values were 7.82, 9.83, 7.0 and 6.71, 7.08 and 8.42, respectively, with P values less than 0.01. Conclusion: It is suggested that previous prostate diseases may be the risk factors of prostate cancer