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目的 探讨我国南方溃疡性结肠炎 (Ulcerativecolitis ,UC)的临床特点和治疗情况。方法 回顾性分析了我院两院 12年来确诊的 141例UC。结果 发现 141例UC中 ,发病以 2 0～ 45岁为主 ,在 5 7～ 6 7岁有较小的第二发病高峰。症状以腹泻 (87 2 % )和大便带血 (87 9% )为主 ,严重并发症及结肠癌少见。病变部位 ,疾病严重度和肠外表现关系密切 ,有肠外表现的患者患重度UC和全结肠炎的比例比无肠外表现的患者高 (P <0 0 1)。结论 传统的内科治疗能取得良好效果 ,但对某些严重和激素依赖病例 ,应尝试运用免疫抑制剂
Objective To investigate the clinical features and treatment of ulcerative colitis (UC) in southern China. Methods Retrospective analysis of 141 cases of UC diagnosed in our hospital in 12 years. The results found that 141 cases of UC, the incidence of 20 to 45 years of age, in 57 to 67 years old have a smaller second peak. The symptoms were diarrhea (87 2%) and bloody stool (87 9%), with severe complications and colon cancer rare. Lesions, severity of disease and extraintestinal manifestations were closely related. Patients with parenteral manifestations had a higher proportion of patients with severe UC and total colitis than those without parenteral manifestations (P <0.01). Conclusion The traditional medical treatment can achieve good results, but for some serious and hormone-dependent cases, we should try to use immunosuppressive agents