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目的:了解武汉地区各型病毒性肝炎患者中庚型肝炎病毒(HGV)感染的情况。方法:用酶联免疫吸附试验(ELISA)及逆转录聚合酶链反应(RT-PCR)方法测定各型病毒性肝炎患者的抗HGV和HGV RNA,并对庚肝病毒感染者进行临床分析。结果:351例各型病毒性肝炎患者中抗HGV阳性者56例,占15.05％;此56例中HGV RNA阳性者21例,占37.50％。各型病毒性肝炎患者中抗HGV阳性率及庚肝抗体阳性者中HGV RNA阳性率分别为:甲肝14.29％(5/35)及20.00％(1/5);乙肝17.29％(37/214)及35.14％(13/37);丙肝14.52％(9/62)及55.56％(5/9);戊肝4.00％(1/25),0.00％(0/1);非甲～戊肝26.67％(4/15),50.00％(2/4)。56例抗HGV阳性者中43例有输血、使用血制品或静脉药癌史,占76.79％。HGV感染在肝炎各临床类型分布为急性、慢性和重型肝炎患者无明显差异,且无性别和年龄分布的差异。HBV重叠感染HGV患者的SALT及TBil水平明显高于单纯HBV感染者(P<0.05),而HGV和其它肝炎病毒((HAV、HCV、HEV)重叠感染患者与单纯其它肝炎病毒感染者的SALT及TBiL水平无明显差异(P>0.05)。结论:武汉地区各型病毒性肝炎患者均可存在HGV感染。HGV可单独感染或与其它病毒混合感染。血液传播是HGV感染的主要途径。乙型肝炎患者合并庚肝病毒重叠感染可加重病情,而甲、丙、戊型肝
Objective: To understand the situation of hepatitis G virus (HGV) infection in various types of viral hepatitis patients in Wuhan. Methods: Anti-HGV and HGV RNA were detected by enzyme linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR) in patients with various types of viral hepatitis and clinical analysis of hepatitis G virus-infected patients. Results: There were 56 cases of anti-HGV positive in 351 cases of various types of viral hepatitis, accounting for 15.05%. Among the 56 cases, 21 cases were positive for HGV RNA, accounting for 37.50%. The positive rates of anti-HGV and HGV RNA in patients with various types of viral hepatitis were 14.29% (5/35) and 20.00% (1/5), 17.29% (37/214) And 35.14% (13/37) respectively; hepatitis C was 14.52% (9/62) and 55.56% (5/9); hepatitis E was 4.00% (1/25) and 0.00% (0/1) % (4/15), 50.00% (2/4). Of the 56 anti-HGV positive cases, 43 had blood transfusions, using blood products or a history of intravenous drug use, accounting for 76.79%. HGV infection in the clinical distribution of hepatitis in acute, chronic and severe hepatitis were no significant differences, and no gender and age distribution differences. The levels of SALT and TBil in HGV patients with overlapping HBV infection were significantly higher than those in HBV-infected patients (P <0.05). However, the SALT and TBil levels in HGV and other hepatitis virus (HAV, HCV, HEV) (P> 0.05) .Conclusion: HGV infection may exist in all kinds of viral hepatitis patients in Wuhan.HGV can be infected alone or mixed with other viruses.The blood transmission is the main way of HGV infection.Hepatitis B Patients with hepatitis G overlap infection can aggravate the disease, and A, C, E-type liver