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目的 :探讨 1型血管紧张素Ⅱ受体 (AT1R)基因多态性与 2型糖尿病肾病 (DN)的关系。方法 :应用PCR DdeⅠ酶切法检测 35例并发DN及 82例无DN的 2型糖尿病 (DM )患者AT1R基因型。结果 :并发DN组突变基因型频率明显高于无DN组 (FisherexactP <0 .0 5,OR =3.2 0 2 ) ,突变等位基因频率亦高 (FisherexactP <0 .0 5,OR =3.2 51) ;Logistic逐步回归分析DN发生危险因素病程、果糖胺、收缩压进入方程。结论 :AT1R基因多态性与 2型糖尿病肾病有相关性 ,携带突变等位基因的 2型糖尿病患者具有发生DN的易感性。
Objective: To investigate the relationship between type 1 angiotensin Ⅱ receptor (AT1R) gene polymorphism and type 2 diabetic nephropathy (DN). Methods: The genotypes of AT1R in 35 patients with DN and 82 patients with type 2 diabetes mellitus (DN) without DN were detected by PCR Dde Ⅰ digestion. Results: The frequencies of the mutant genotypes in patients with DN were significantly higher than those without DN (FisherexactP <0.05, OR = 3.2 0 2), and the frequency of the mutant alleles was also high (FisherexactP <0.05, OR = 3.251) ; Logistic stepwise regression analysis of DN risk factors duration, fructosamine, systolic blood pressure into the equation. CONCLUSION: AT1R gene polymorphism is associated with type 2 diabetic nephropathy. Patients with type 2 diabetes who carry the mutant allele have a predisposition to develop DN.