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论述了以聚甲基丙烯酸甲酯(PMMA)为盖板和底板、以聚酯膜为通道层的微流控芯片的制作流程。设计并制作了多个形状不同的微流控芯片,进行了实验研究和数据分析,系统研究了T型微通道法液-液两相产生微液滴的过程。分别从微流控芯片的通道尺寸、形状和流量比三个方面探讨了T型微通道法产生微液滴的尺寸、频率和形状的变化规律。同时进行了微液滴分裂的基础实验研究,使用多相流法通过液相间的剪切力和表面张力的作用使母液滴分裂成两个子液滴。通过改变微通道的宽度,研究了微液滴分裂产生子液滴的比例大小的变化规律。
The production process of microfluidic chip with polymethylmethacrylate (PMMA) as the cover and the floor and the polyester film as the channel layer was discussed. Several microfluidic chips with different shapes were designed and fabricated. The experimental research and data analysis were carried out. The process of micro-droplet generation in liquid-liquid two-phase was studied systematically. The changes of size, frequency and shape of microdroplets generated by T-type microchannels were discussed respectively from three aspects: channel size, shape and flow rate. At the same time, the basic experimental study of microdisruption was carried out. The multiphase flow method was used to separate the mother liquid droplets into two sub-liquid droplets by the shear force and surface tension of the liquid phase. By changing the width of microchannels, the variation of the proportion of sub-droplets generated by the micro-droplets splitting was studied.