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登革热(dengue fever,DF)是一种主要在热带、亚热带地区流行的蚊媒传染疾病,近年来疫情愈发严重。登革病毒(dengue virus,DENV)非结构蛋白(non-structural protein,NS)NS5是所有黄病毒属蛋白中最大也是最保守的。DENV NS5具有三种酶活性:甲基转移酶(methyltransferase,MTase)、核苷酸末端转移酶(terminal nucleotide transferase,TNTase)和RNA依赖的RNA聚合酶(RNA dependent RNA polymerase,RdRp)。DENV NS5的MTase和RdRp活性在结构和功能上具有鲜明特点,在病毒基因组复制过程起着核心作用,因此NS5蛋白具有成为阻断或抑制病毒增殖靶标的潜力。本文综述了近年来DENV NS5的研究进展。
Dengue fever (DF) is a mosquito-borne infectious disease that is endemic in the tropics and subtropics. The epidemic has become more serious in recent years. Dengue virus (DENV) Non-structural protein (NS) NS5 is the largest and most conserved among all flavivirus proteins. DENV NS5 has three enzyme activities: methyltransferase (MTase), terminal nucleotide transferase (TNTase) and RNA dependent RNA polymerase (RdRp). The structural and functional distinctness of MTase and RdRp activity of DENV NS5 plays a central role in viral genome replication and therefore NS5 protein has the potential to block or inhibit viral proliferation. This review summarizes the research progress of DENV NS5 in recent years.