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IL-15具有促进自然杀伤细胞及活化外周血T细胞增殖的功能,与IL-2共属于四螺旋束(four-he-lix buddle)细胞因子家族。研究表明,IL-15可能凭借IL-2受体(IL-2R)的成分行使结合及信号传导功能。高亲合的IL-2R复合物包含三个亚单位即IL-2Rα、β及γ链,其中隶属于hematopietin受体超家族的β及γ链为高亲合的IL-2结合及信号传导所需,而α链(又称P55)系一种低亲合力的、非信号结合的亚单位,是结合蛋白家族内唯一已知的细胞因子受体成员。已知IL-15的活化需要IL-2R的β
IL-15 has the function of promoting the proliferation of natural killer cells and activated peripheral blood T cells, and belongs to the family of four-he-lix buddle cytokines together with IL-2. Studies have shown that IL-15 may exert binding and signaling functions by virtue of the composition of IL-2 receptor (IL-2R). The high-affinity IL-2R complex contains three subunits, IL-2Rα, β and γ, of which the β and γ chains belonging to the hematopietin receptor superfamily are high-affinity IL-2 binding and signaling The alpha chain, also known as P55, is a low avidity, non-signaling subunit that is the only known member of the cytokine receptor within the binding protein family. It is known that the activation of IL-15 requires beta of IL-2R