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用研磨法制备了羟丙基-β-环糊精(Hp-β-CD)与α-山竹黄酮(α-MAG)的包合物,由紫外和红外吸收光谱、差示扫描量热分析和1HNMR对包合物进行了表征,并用紫外分光光度法测定了包合物的溶解度、表观包合稳定常数和包合反应的热力学参数ΔG,ΔH和ΔS。结果表明,Hp-β-CD能与α-MAG形成稳定的1∶1包合物,表观包合稳定常数K为2.11×103L/mol,加入Hp-β-CD后,α-MAG溶解度大大增加。包合反应主要由焓变控制,驱动力为范德华力和疏水作用力。
The inclusion complex of hydroxypropyl-β-cyclodextrin (Hp-β-CD) and α-manganous flavin (α-MAG) was prepared by the grinding method. The inclusion complex was characterized by UV and IR, differential scanning calorimetry 1HNMR was used to characterize the inclusion complex. The solubility, apparent stability constant and the thermodynamic parameters ΔG, ΔH and ΔS of the inclusion complex were determined by UV spectrophotometry. The results showed that Hp-β-CD could form a stable 1: 1 inclusion complex with α-MAG with an apparent inclusion constant K of 2.11 × 103 L / mol. The solubility of α-MAG was significantly increased by adding Hp-β-CD increase. Inclusion reaction is mainly controlled by enthalpy change, the driving force is van der Waals forces and hydrophobic force.