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目的观察I125粒子永久植入联合高强度超声聚焦刀(HIFU)治疗前列腺癌的疗效观察。方法在直肠B超引导下,经会阴模板穿刺将I125粒子植入到靶组织中,再行高强度超声聚焦刀治疗,治疗前列腺癌病人8例。结果随访6～12个月,6例PSA术后降至正常,直肠B超发现前列腺明显缩小,部分钙化改变,2例术后PSA下降又反弹升高,需加用内分泌类药物治疗。8例手术过程顺利,无出现严重并发症。结论I125粒子植联合高强度超声聚焦刀治疗前列腺癌疗效满意,是一种微创,安全,并发症少的方法,有良好的临床应用前景。
Objective To observe the curative effect of I125 particles permanently implanted combined with high intensity ultrasound focusing knife (HIFU) in the treatment of prostate cancer. Methods Under the guidance of rectum B-ultrasound, I125 particles were implanted into the target tissue through perineal template puncture, and then treated with high-intensity ultrasound focused knife to treat 8 cases of prostate cancer. Results The follow-up ranged from 6 to 12 months. Six patients with PSA were reduced to normal after operation. Rectal B ultrasound showed that the prostate was significantly reduced, partial calcification was changed, and two postoperative PSA decreased and then rebounded. Endocrine therapy was required. 8 cases of surgical procedures smoothly, no serious complications. Conclusion I125 particle implantation combined with high-intensity ultrasound focused knife treatment of prostate cancer is satisfactory, is a minimally invasive, safe, less complications, and has good clinical application prospects.