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目的探讨米非司酮配伍米索前列醇在孕12~23周引产中的应用效果。方法回顾性分析米非司酮配伍米索前列醇,用于100例孕12~23周妊娠妇女在引产中的临床疗效及安全性,并与利凡诺尔引产结果进行比较。结果显示米非司酮配伍米索前列醇引产成功率为98%,显著高于利凡诺尔引产,产程较利凡诺尔引产缩短,出血量和胎盘滞留率显著降低,未见子宫破裂等并发症发生。结论米非司酮配伍米索前列醇是一种简便、安全、有效的孕12~23周引产方法,在临床上有值得推广应用的价值。
Objective To investigate the effect of mifepristone and misoprostol in induction of labor during 12 ~ 23 weeks of gestation. Methods The clinical efficacy and safety of mifepristone and misoprostol were retrospectively analyzed. The clinical efficacy and safety of mifepristone and misoprostol in 100 pregnant women with gestational age of 12 ~ 23 weeks were compared with that of rivanol induction. The results showed that the success rate of mifepristone and misoprostol induction of labor was 98%, significantly higher than rivanol induction of labor, labor less than rivanol induction of labor shortening, bleeding and placental retention rate was significantly reduced, no complications such as uterine rupture occur. Conclusion Mifepristone combined with misoprostol is a simple, safe and effective method of induction of labor during 12 ~ 23 weeks of gestation, which is worthy of popularization and application in clinic.