论文部分内容阅读
目的 :探讨喉癌及癌旁组织中抑癌基因p2 7及癌基因细胞周期素D1的表达状况 ,以及p2 7与细胞周期素D1的表达与喉癌临床特征之间的关系。方法 :用免疫组织化学S P法对 38例喉癌组织 ,癌旁组织进行p2 7及细胞周期素D1检测。结果 :p2 7及细胞周期素D1表达在喉癌和癌旁组织之间各有统计学差异。p2 7及细胞周期素D1表达与颈淋巴结转移和患者预后有相关性 (P <0 .0 5 ) ;且大多数受检喉癌组织中 ,p2 7与细胞周期素D1呈反方向表达。结论 :检测p2 7与细胞周期素D1有助于判断喉癌预后。
Objective: To investigate the expression of tumor suppressor gene p2 7 and oncogene cyclin D1 in laryngeal carcinoma and paracancerous tissues and the relationship between p27 and cyclin D1 expression and clinical features of laryngeal carcinoma. Methods: The expressions of p27 and cyclin D1 in 38 cases of laryngeal carcinoma tissues and adjacent tissues were detected by immunohistochemical SP method. Results: The expressions of p27 and cyclin D1 were significantly different between laryngeal carcinoma and adjacent normal tissues. The expression of p27 and cyclin D1 was correlated with the metastasis of cervical lymph nodes and the prognosis of patients (P <0.05). In the majority of the examined laryngeal squamous cell carcinomas, the expression of p27 was opposite to that of cyclin D1. Conclusion: The detection of p27 and cyclin D1 is helpful to predict the prognosis of laryngeal cancer.