目的　探讨妊娠肝内胆汁淤积症患者胎盘血管内皮生长因子 (VEGF)与胎儿窘迫的关系。方法　采用蛋白免疫印迹(westernblot )测定胎盘VEGF含量 ,其中妊娠肝内胆汁淤积症患者 (ICP组 ) 3 3例 ,正常晚期妊娠妇女 3 0例 (对照组 )。采用免疫组织化学方法测定VEGF在胎盘表达部位 ,及胎盘血管密度。结果　ICP组较对照组胎盘VEGF表达部位相同 ,但表达量明显减少 (P <0 0 1) ,且病情越重表达越少 ;ICP组较NLP组胎盘血管密度明显减少 (P <0 0 5 )。结论　ICP患者胎盘分泌VEGF减少造成胎盘血管形成不良 ,血管密度减少、血管通透作用下降 ,由于宫缩等刺激因素 ,可致胎儿宫内窘迫 Objective To investigate the relationship between placental vascular endothelial growth factor (VEGF) and fetal distress in patients with intrahepatic cholestasis of pregnancy. Methods Placental VEGF levels were determined by western blotting, including 33 patients with ICP (ICP group) and 30 normal pregnant women (control group). Immunohistochemistry was used to determine the expression of VEGF in the placenta and placental vascular density. Results Compared with the control group, the expression of VEGF in the placenta of ICP group was the same, but the expression level was significantly decreased (P <0.01), and the more severe the expression of ICP was. ICP group showed a significant decrease in placental vascular density compared with NLP group (P <0.05) . Conclusions The decrease of placental secretion of VEGF in ICP patients results in poor placental angiogenesis, decreased vascular density and decreased vascular permeability. As a result of contractile factors such as uterine contraction, fetal distress