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目的 研究云南肺癌点状高发区———宣威地区组织学类型具有地方特征肺癌的发病机制。方法 以宣威地区 2 9例肺癌和非宣威地区 11例肺癌 ,应用免疫组化和原位分子杂交法分别检测Ki 6 7抗原和人端粒酶RNA成分 (hTR)。结果 宣威地区肺癌组Ki 6 7标记率为 34.4%± 17.8% ,明显高于非宣威地区肺癌组 (2 1.9%± 11.2 % ) ,差异有显著性 (P =0 .0 45 ) ;宣威地区肺癌组hTR检出率为 5 5 .2 % ,与非宣威地区组 (72 .7% )的差异无显著性 (χ2 =1.0 2 ,P =0 .31) ;非宣威地区肺癌组患者癌旁正常支气管上皮和肺泡上皮中未检出hTR ,但在其中部分病例 (4 5 .5 % ,5 / 11)的癌旁增生Ⅱ型肺泡上皮中检出hTR。结论 宣威地区肺癌较特异的病因引起细胞增殖动力学特征异于普通人群肺癌 ;hTR作为肺癌标志物或应用于肺癌早期诊断有一定价值
Objective To study the pathogenesis of lung cancer in Yunnan Province, where the spotty high-risk area of lung cancer is located in Xuanwei area. METHODS: Ki67 antigen and human telomerase RNA (hTR) were detected by immunohistochemistry and in situ hybridization in 29 lung cancers and 11 non-Xuanwei lung cancers in Xuanwei area. Results The Ki 6 7 labeling rate of lung cancer in Xuanwei area was 34.4% ± 17.8%, which was significantly higher than that of non-Xuanwei lung cancer group (2 1.9% ± 11.2%). The difference was significant (P = 0.045); The detection rate of hTR in the lung cancer group in Wei area was 55.2%, which was not significantly different from that in non-Xuanwei area group (72.7%) (χ2 = 1.02, P = 0.31); lung cancer in non-hoxwean area No hTR was detected in the normal bronchial epithelium and alveolar epithelium adjacent to the tumors of the patients, but hTR was detected in some cases (45.5%, 5/11) of the para-tumoral hyperplasia type II alveolar epithelium. Conclusion The specific etiology of lung cancer in Xuanwei area causes the cell proliferation kinetics to be different from that in the general population. hTR has a certain value as a lung cancer marker or early diagnosis of lung cancer.