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目的:探讨影响早期阴茎癌患者阴茎保留术预后的因素。方法:回顾性分析2007年1月至2014年12月行阴茎保留术的早期阴茎癌患者45例,年龄23~65岁,平均45.6岁。应用Kaplan-Meier生存分析法计算无局部复发生存率,对随访数据进行单因素及Cox多因素回归分析,分析因素包括患者年龄、婚姻状况、肿瘤原发部位、肿瘤大小、术后吸烟及性生活情况、组织学分级、TNM分期。结果:所有患者1年无局部复发生存率为95.5%,3年无局部复发生存率为52.2%。Cox多因素回归分析表明肿瘤组织学分级(P=0.039)及术后性生活变化(P=0.049)对阴茎保留术的预后有统计学意义。Logistic回归分析发现患者年龄对于组织学分级有显著影响(P=0.014)。结论:组织学分级和术后性生活情况的改变是阴茎保留术预后的独立风险因素,而年龄通过影响组织学分级与患者预后相关。
Objective: To explore the factors that affect the prognosis of penile cancer patients with early stage penile cancer. Methods: Forty-five patients with penile cancer who underwent penile retention from January 2007 to December 2014 were retrospectively analyzed. The average age was 45.6 years (range, 23-65 years). Kaplan-Meier survival analysis was used to calculate the local recurrence-free survival rate. The follow-up data were analyzed by single factor and Cox regression analysis. The factors including patient age, marital status, tumor location, tumor size, postoperative smoking and sex life Situation, histological grade, TNM staging. Results: All patients had no local recurrence after 1 year 95.5%, and no local recurrence after 3 years 52.2%. Cox multivariate regression analysis showed that histological grade (P = 0.039) and postoperative sexual life changes (P = 0.049) had a statistically significant prognosis for penile retention. Logistic regression analysis showed that patient age had a significant effect on histological grade (P = 0.014). Conclusion: Histological grading and changes of postoperative sexual life are independent risk factors for the prognosis of penile retention. However, age is influenced by histological grade and prognosis.