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目的探讨超体质量和肥胖成人肺通气功能与脂联素、瘦素水平的相关性。方法 305例健康体检者依据体质量指数分为正常组100例,超体质量组103例,肥胖组102例,应用肺功能测定仪检测3组潮气量、每分钟静息通气量、用力肺活量、第1秒用力呼气容积、最高呼气流速、第1秒用力呼气容积占肺总量的百分比、第1秒用力呼气容积/用力肺活量、50%肺活量最大呼气流量、25%肺活量最大呼气流量等肺通气功能指标。采集每组各30例受试者血清标本,应用ELISA法测定脂联素、瘦素水平,采用单因素方差分析和Pearson相关分析肺通气功能与脂联素、瘦素的关系。结果超体质量组用力肺活量((85.74±13.94)%)、第1秒用力呼气容积((84.52±14.62)%)较正常组((95.79±26.83)%、(92.65±26.93)%)明显降低(P<0.01),第1秒用力呼气容积/用力肺活量((103.4±13.05)%)较正常组((99.98±11.88)%)升高(P<0.05);肥胖组每分钟静息通气量((88.73±8.44)%)、潮气量((86.70±10.23)%)、用力肺活量((82.85±13.34)%)、第1秒用力呼气容积((82.74±14.18)%)均低于正常组((96.47±10.78)%、(96.20±25.21)%、(95.79±26.83)%、(92.65±26.93)%)(P<0.05或P<0.01),第1秒用力呼气容积/用力肺活量((103.17±8.99)%)高于正常组((99.98±11.88)%)(P<0.05);超体质量组、肥胖组脂联素((9.48±1.05)、(7.88±1.42)μg/L)低于正常组((10.06±1.04)μg/L)(P<0.01),超体质量组与肥胖组比较差异无统计学意义(P>0.05);肥胖组瘦素水平((8.42±0.57)μg/L)高于超体质量组((8.12±0.49)μg/L)和正常组((8.05±0.64)μg/L)(P均<0.05),超体质量组与正常组比较差异无统计学意义(P>0.05);脂联素与潮气量、25%肺活量最大呼气流量呈正相关(r=0.270,P=0.019;r=0.217,P=0.031),瘦素与第1秒用力呼气容积呈负相关(r=-0.275,P=0.009)。结论脂联素、瘦素与肥胖成人肺通气功能受损有相关性。
Objective To explore the correlation between lung function and adiponectin and leptin levels in overweight and obesity adults. Methods According to the body mass index, 305 healthy subjects were divided into normal group (n = 100), super body mass group (n = 103) and obesity group (n = 102). The tachycardia, resting ventilation per minute, forced vital capacity 1 second forced expiratory volume, maximum expiratory flow, forced expiratory volume in 1 second as a percentage of total lung volume, forced expiratory volume in 1 second / forced vital capacity, maximal expiratory flow of 50% of vital capacity, maximal expiratory volume of 25% Expiratory flow and other pulmonary ventilation function indicators. Serum samples were collected from 30 subjects in each group. The levels of adiponectin and leptin were measured by ELISA. The relationship between lung ventilation and adiponectin and leptin was analyzed by one-way ANOVA and Pearson correlation analysis. Results Compared with the normal group (95.79 ± 26.83%, (92.65 ± 26.93)%), the forced vital capacity of the overweight group was (85.74 ± 13.94)% and the forced expiratory volume of the second second was (84.52 ± 14.62)% (P <0.05). The forced expiratory volume / forced vital capacity at 1 second (103.4 ± 13.05)% was significantly higher than that of the normal group (99.98 ± 11.88%) (P <0.05) (88.73 ± 8.44)%, tidal volume (86.70 ± 10.23)%, forced vital capacity (82.85 ± 13.34)%, and forced expiratory volume in 1 second (82.74 ± 14.18)%, respectively) (P <0.05 or P <0.01) in the normal group (96.47 ± 10.78%, (96.20 ± 25.21)%, (95.79 ± 26.83)%, (92.65 ± 26.93)%, The forced vital capacity ((103.17 ± 8.99)%) was higher than that of the normal group (99.98 ± 11.88%) (P <0.05). The levels of adiponectin in the overweight group and obesity group were (9.48 ± 1.05) and (7.88 ± 1.42) (P <0.01). There was no significant difference between obesity group and obesity group (P> 0.05). The level of leptin in obesity group was significantly higher than that in control group (P <0.01) (8.42 ± 0.57) μg / L) were higher than that of the normal control group (8.12 ± 0.49) μg / L and the normal control group (8.05 ± 0.64) μg / L, P <0.05) Group difference was not statistically significant (P> 0.05) (R = 0.270, P = 0.019; r = 0.217, P = 0.031). There was a negative correlation between leptin and forced expiratory volume in the first second (r = 0.270, r = = -0.275, P = 0.009). Conclusion Adiponectin and leptin are associated with impaired lung ventilation in obese adults.