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[目的]观察补阳还五汤对脑缺血神经功能损伤的影响。[方法]40只雄性SD大鼠随机分成假手术组、模型组、补阳还五汤高、低剂量组。根据Kirino的方法制作沙鼠前脑缺血模型。观察脑缺血72h后海马区神经细胞形态、凋亡细胞变化;测试动物学习记忆功能综合运动功能。[结果](1)补阳还五汤能显著降低脑缺血后凋亡神经细胞数量;(2)补阳还五汤能改善脑缺血后神经功能损伤。[结论]补阳还五汤可抑制全脑缺血大鼠神经细胞凋亡,并由此改善脑缺血后的神经功能损伤。
[Objective] To observe the effect of Buyang Huanwu Decoction on nerve function damage after cerebral ischemia. [Methods] Forty male SD rats were randomly divided into sham operation group, model group and Buyang Huanwu Decoction high and low dose groups. Gerbil forebrain ischemia model was made according to Kirino’s method. The changes of neuronal morphology and apoptotic cells in hippocampus 72h after cerebral ischemia were observed. The motor function of learning and memory was tested. [Results] (1) Buyang Huanwu decoction can significantly reduce the number of apoptotic neurons after cerebral ischemia; (2) Buyanghuanwu decoction can improve neurological injury after cerebral ischemia. [Conclusion] Buyang Huanwu decoction can inhibit the neuronal apoptosis in rats with global cerebral ischemia and thus improve the neurological impairment after cerebral ischemia.