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目的:回顾性分析原发性乳腺恶性淋巴瘤的发病、诊断、治疗与预后。方法:收集我院1985年1月至2000年12月13例原发性乳腺恶性淋巴瘤进行回顾性分析。结果:13例均为弥漫型非何杰金氏淋巴瘤,占同期乳腺恶性肿瘤的0.35%。7例行乳腺癌根治术或改良根治术,术后化疗,5年生存率为52.0%;4例行局部切除术加化疗和/或放疗,2例复发;2例单纯化疗。总的5年生存率为47%。结论:肿块细针穿刺涂片未能确诊,光镜下组织学检查可确诊,免疫组化检查可进一步确定诊断;本病在局部治疗的基础上加全身化疗,效果良好;手术切除局部治疗效果良好,可作为首选;预后与临床分期和治疗措施是否得当有关。
Objective: To retrospectively analyze the pathogenesis, diagnosis, treatment and prognosis of primary breast malignant lymphoma. METHODS: A retrospective analysis of 13 cases of primary malignant lymphoma of the breast was performed in our hospital from January 1985 to December 2000. Results: All 13 cases were diffuse non-Hodgkin’s lymphoma, which accounted for 0.35% of malignant tumors of the same period. Seven patients underwent radical mastectomy or modified radical mastectomy, and postoperative chemotherapy had a 5-year survival rate of 52.0%; 4 patients underwent local resection plus chemotherapy and/or radiotherapy, and 2 patients relapsed; 2 patients received chemotherapy alone. The overall 5-year survival rate was 47%. Conclusion: The mass fine needle aspiration puncture smear cannot be diagnosed. The histological examination under light microscope can confirm the diagnosis. The diagnosis can be further confirmed by immunohistochemical examination. This disease is based on topical therapy plus systemic chemotherapy with good results; Good, can be used as the first choice; prognosis and clinical staging and treatment measures are appropriate.