论文部分内容阅读
目的探讨结核病患者血清维生素D水平与其携带结核杆菌耐药情况的相关性。方法选取2013年1—6月在医院就诊的120例痰培养阳性的结核病患者作为研究对象,根据患者维生素D水平分为4组:维生素D严重缺乏组(<10ng/mL)、维生素D缺乏组(10~19ng/mL)、维生素D不足组(20~29ng/mL)及维生素D充足组(≥30ng/mL),使用比例法对链霉素(SM)、异烟肼(INH)、乙胺丁醇(EMB)、利福平(RFP)4种抗结核药物进行药敏试验,分析不同血清维生素D水平对4种抗结核药物的耐药情况。结果总耐药率分别为维生素D严重缺乏组66.7%(20/30)、维生素D缺乏组56.7%(17/30)、维生素D不足组33.3%(10/30)、维生素D充足组26.7%(8/30),差异有统计学意义(P<0.01)。4种抗结核药的耐药率均随着患者血清维生素D水平的下降而升高,但统计学分析结果显示,只有EMB的耐药率差异有统计学意义(P<0.05)。结论维生素D缺乏的结核病患者,其出现耐药的可能性会有所增加。
Objective To investigate the correlation between the level of serum vitamin D in patients with tuberculosis and the drug resistance of Mycobacterium tuberculosis. Methods A total of 120 patients with sputum culture-positive TB from January to June 2013 were enrolled in this study. Patients were divided into 4 groups according to their vitamin D levels: severe vitamin D deficiency (<10ng / mL), vitamin D deficiency (10 ~ 19ng / mL), vitamin D deficiency group (20 ~ 29ng / mL) and vitamin D adequate group (≥30ng / mL) Amine butanol (EMB) and rifampicin (RFP) were tested for susceptibility to four anti-TB drugs. Results The total drug resistance rates were 66.7% (20/30) for vitamin D deficiency group, 56.7% (17/30) for vitamin D deficiency group, 33.3% (10/30) for vitamin D deficiency group and 26.7% for vitamin D deficiency group (8/30), the difference was statistically significant (P <0.01). The resistance rates of 4 kinds of anti-TB drugs all increased with the decrease of serum vitamin D level in patients, but statistical analysis showed that there was only significant difference in the drug resistance rate of EMB (P <0.05). Conclusion In patients with vitamin D-deficient tuberculosis, there is an increased likelihood of emergence of drug resistance.