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关于对红细胞及血小板的自身免疫性疾病概念了解较多,其发生机理逐渐被理解,但相比之下对白细胞特别是对粒性白细胞的自身免疫性疾病参与的抗原和抗体方面问题只是在几年前才有报导,因此,抗粒性白细胞抗体是一个新的概念。粒性白细胞膜表面抗原可分为两大系统,其一为HLA系统;其二为粒性白细胞特异的抗原。后者由于基因位点不同又分为NA系统(NA_1,NA_2抗原),NB系统(NB_1抗原),NC系统(NC_1抗原),ND(ND_1抗原)和9系统(9a抗原)等。粒性白细胞特异性抗体及其临床意义 1.同族免疫新生儿嗜中性白细胞减少
There is a growing understanding of the concept of autoimmune diseases of erythrocytes and platelets, and their pathogenesis is gradually understood, but in contrast the problems with antigens and antibodies involved in leukocytes, especially autoimmune diseases of granulocytes, are only a few Reported only years ago, therefore, anti-granulocyte antibodies is a new concept. Granulocyte membrane antigen can be divided into two major systems, one for the HLA system; the second is a granulocyte-specific antigen. The latter is divided into NA system (NA 1, NA 2 antigen), NB system (NC 1 antigen), NC system (NC 1 antigen), ND (ND 1 antigen) and 9 system (9a antigen) due to different genetic loci. Granulocyte-specific antibodies and its clinical significance 1. Simian immune neonate neutropenia