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目的探讨雌激素调节蛋白PS2在乳腺癌中的表达及其临床病理间的关系。方法采用免疫组织化学SABC法对68例乳腺癌中ER、PR及PS2进行检测,分析其与ER、PR及预后的关系。结果PS2与ER显著正相关。在ER(+)PR(+)的病例中,PS2阳性表达率为52.0%,而在ER(-)PR(-)的病例中,PS2阳性率仅为14.3%,二者相比差异有统计学意义(P<0.01)。PS2的表达与患者年龄、肿瘤大小无关(P>0.05),而与腋下淋巴结状况有关(P<0.01)。结论在乳腺癌中PS2的表达与ER、PR呈正相关关系,并与腋下淋巴结状况有关。PS2可以作为预测乳腺癌预后的一项重要指标。
Objective To investigate the expression of estrogen regulatory protein PS2 in breast cancer and its relationship with clinicopathology. Methods Immunohistochemical SABC method was used to detect ER, PR and PS2 in 68 cases of breast cancer, and its relationship with ER, PR and prognosis was analyzed. Results PS2 was positively correlated with ER. In the cases of ER (+) PR (+), the positive rate of PS2 was 52.0%, while in the cases of ER (-) PR (-), the positive rate of PS2 was only 14.3% Significance (P <0.01). The expression of PS2 was not associated with the age and tumor size (P> 0.05), but with the status of axillary lymph nodes (P <0.01). Conclusion The expression of PS2 in breast cancer is positively correlated with ER and PR, and is related to the status of axillary lymph nodes. PS2 can be used as a predictor of breast cancer prognosis is an important indicator.