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干眼是临床最为常见的眼表疾病,其发病机制尚不清楚,建立有效的动物模型对于其机制的研究显得尤为重要。目前通过诱导动物自身免疫反应、摘除泪腺、阻断神经、使用副交感神经抑制药物等方法建立泪液生成不足型干眼动物模型;也可通过烧灼睑板腺、减少瞬目频率、喂养维生素A缺乏饲料、使用防腐剂、增加泪液渗透压、智能环境控制系统等方法建立蒸发过强型干眼动物模型;还可通过改变性激素水平、应用副交感神经抑制药物合并控制环境条件、摘除泪腺合并使用防腐剂等方法建立混合型干眼动物模型。就常见干眼动物模型作综述。
Dry eye is the most common clinical ocular surface disease, the pathogenesis is not clear, to establish an effective animal model for the study of its mechanism is particularly important. At present, animal models of dry eye are established by inducing animal’s autoimmune reaction, removing lacrimal gland, blocking nerves, using parasympathetic inhibitory drugs and the like; or by burning meibomian glands to reduce the frequency of blinking and feeding vitamin A deficiency feed , The use of preservatives to increase tear penetration pressure, intelligent environmental control systems and other methods to establish evaporative dry eye animal model; also by changing the sex hormone levels, the application of parasympathetic inhibitory drugs combined with the control of environmental conditions, removal of the lacrimal gland combined with preservatives Methods A mixed dry eye animal model was established. Common dry eye animal models for review.