1概述遗传性痉挛性截瘫(hereditary spastic paraplegia,HSP或SPG),又名家族性Strmpell-Lorrain痉挛性截瘫,是一类主要由皮质脊髓束受损所引起的遗传性、神经退行性变的疾病,具有明显的遗传异质性,临床表现主要为进行性的痉挛性步态、双下肢肌张力增高、腱反射亢进、踝阵挛、 1 Overview Hereditary spastic paraplegia (HSP or SPG), also known as familial Strmpell-Lorrain Spastic paraplegia, is a group of hereditary spastic paraplegia caused mainly by genetic damage, neurodegeneration Of the disease, with obvious genetic heterogeneity, the clinical manifestations of progressive spastic gait, increased muscle tension in both lower extremities, tendon hyperreflexia, ankle clonus,