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目的探讨引起心肌肌钙蛋白I(cTnI)测定结果假阳性的原因。方法测定非急性心肌梗塞的入院患者的血清cTnI,统计病种和计算假阳性率。结果被确诊非心脏疾病患者有164例,其中22例cTnI为假阳性(男性有15例,女性有7例),引起cTnI假阳性病种分布如下:消化道疾病1例(4.55%)、脑疾病5例(22.73%)、肾脏疾病2例(9.09%)、糖尿病3例(13.64%)、高血压5例(22.73%)、呼吸道疾病5例(4.55%)、肝脏疾病1例(4.55%)。结论cTnI目前被认为是最具心脏特异性,且最有价值的心肌损伤指标之一,但其检测方法尚未标准化,循环中cTnI浓度的检测也受多种因素干扰,AMI和ACS以外的疾患的cTnI的假阳性也值得临床注意。
Objective To investigate the causes of false positive results of cardiac troponin I (cTnI) assay. Methods Serum levels of cTnI, statistical illnesses and calculated false positive rates were determined in hospitalized patients with non-acute myocardial infarction. Results A total of 164 patients were diagnosed with noncardiac disease. Of the 22 patients, cTnI was false positive (15 in males and 7 in females). The distribution of cTnI false positives was as follows: 1 case (4.55%) of digestive diseases, (22.73%), 2 cases of renal disease (9.09%), 3 cases of diabetes mellitus (13.64%), 5 cases of hypertension (22.73%), 5 cases of respiratory disease (4.55%) and 1 case of liver disease (4.55% ). Conclusions cTnI is currently considered as one of the most cardiac specific and most valuable indicators of myocardial damage. However, its detection method has not been standardized. The detection of cTnI in circulation is also affected by many factors, and AMI and ACS False positives for cTnI are also worthy of clinical attention.