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目的探讨肺结核治疗时产生肝毒性的危险因素。方法对2004年6月～2005年10月住院治疗的781例初治肺结核病人产生肝毒性的危险因素进行调查,并对其危险因素进行单因素和多因素非条件Logistic回归分析。结果初治肺结核产生肝毒性的危险因素为饮酒、营养不良、HBsAg(+)、性别、高龄、高血糖。其比值比(OR)和95%可信区间(95%CI)分别为2.085(1.511～2.878)、0.450(0.294～0.690)、2.174(1.340～3.527)、0.423(0.232～0.770)、2.200(1.474～3.283)、5.648(3.546～6.457)。结论加强对肺结核治疗时发生肝毒性危险因素的预防干预,对提高肺结核治愈率具有重要意义。
Objective To investigate the risk factors of hepatotoxicity in the treatment of pulmonary tuberculosis. Methods The risk factors of hepatotoxicity in 781 newly diagnosed tuberculosis patients hospitalized from June 2004 to October 2005 were investigated. Univariate and multivariate non-conditional Logistic regression analysis was performed on the risk factors. Results The risk factors of hepatotoxicity in newly diagnosed tuberculosis were alcohol consumption, malnutrition, HBsAg (+), gender, age and hyperglycemia. The odds ratio (OR) and 95% confidence interval (95% CI) were 2.085 (1.511-2.878), 0.450 (0.294-0.690), 2.174 (1.340-3.527), 0.423 (0.232-0.770), 2.200 ~ 3.283), 5.648 (3.546 ~ 6.457). Conclusion To strengthen prevention and treatment of the risk factors of hepatotoxicity in the treatment of pulmonary tuberculosis is of great significance to improve the cure rate of pulmonary tuberculosis.