论文部分内容阅读
目的研究胃癌高发区不同人群幽门螺杆菌（Ｈｐ）ｃａｇＡ＋亚型感染状况，探讨ＨｐｃａｇＡ＋亚型感染与胃癌高发流行的关系．方法用ＥＬＩＳＡ方法检测了全部受检者的抗Ｈｐ抗体及抗ｃａｇＡ抗体，并用１３Ｃ尿素酶呼吸实验（１３Ｃ－ＵＢＴ）方法检测了７０名儿童Ｈｐ感染状况．结果胃癌高发区成人Ｈｐ感染率为７４７％，儿童Ｈｐ感染率为６８６％；成人ｃａｇＡ＋亚型感染率为６５％，儿童为７１４％．７７名癌症患者的Ｈｐ和ｃａｇＡ＋亚型感染率均为５９７％，其中胃癌患者（ｎ＝３８）Ｈｐ和ｃａｇＡ＋亚型感染率分别为５０％和５５３％，均低于其他癌症患者（ｎ＝３９）的感染率（６９２％和６４１％）．结论胃癌高发区成人、儿童及癌症患者ＨｐｃａｇＡ＋亚型感染率相当高，表明Ｈｐ感染，尤其是ｃａｇＡ＋的Ｈｐ感染与当地胃癌高发有明显的关系．
Objective To investigate the infection status of Helicobacter pylori (Hp) cagA + subtypes in different populations with high incidence of gastric cancer, and explore the relationship between HpcagA + subtype infection and the high incidence and prevalence of gastric cancer. Methods Anti-Hp antibody and anti-cagA antibody were detected in all subjects by ELISA. Hc infection status was detected in 13 children by 13CUBT breath test (13C-UBT). Results The prevalence of Hp infection was 74.7% in children with high incidence of gastric cancer and 68.6% in children. The incidence of adult cagA+ infection was 65% in children and 71.4% in children. The infection rate of Hp and cagA+ subtypes in all 77 cancer patients was 59.7%. Among them, the infection rates of Hp and cagA+ subtypes in gastric cancer patients (n=38) were 50% and 55.4%, respectively, which were lower than those in other cancer patients. The infection rate was (n=39) (69. 2% and 64.1%). Conclusion The infection rate of HpcagA+ is very high in adults, children and cancer patients with high incidence of gastric cancer, indicating that Hp infection, especially cagA+ Hp infection, has a significant relationship with the high incidence of local gastric cancer.