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前列腺特异性抗原(Prostate-specific antigen,PSA)于1971年由Grim从人精浆中提取,Hara首先描述,1979年Wang等用免疫沉淀法成功地从人前列腺组织中将其分离出,并认识到它在前列腺癌中的重要性。以后的研究发现,尽管正常男性血清中PSA浓度很低,但通过免疫学检测方法仍能被测出,而且大多数前列腺癌患者血清中PSA水平超过正常值。由于PSA的特异性和敏感性已成为比酸性磷酸酶更为重要的前列腺癌肿瘤标记物,所以它的应用亦日趋广泛。本文就PSA某些基础方面的研究做一综述。
Prostate-specific antigen (PSA) was extracted from human seminal plasma by Grim in 1971. Hara firstly described that in 1979, Wang et al. Successfully isolated it from human prostate tissue by immunoprecipitation and recognized To its importance in prostate cancer. Subsequent studies found that despite the low PSA concentration in normal male sera, immunological testing can still be performed and PSA levels in most prostate cancer patients exceed normal levels. Because PSA specificity and sensitivity have become more important than acid phosphatase prostate cancer tumor markers, so its application is also increasingly widespread. This article reviews some of the basic aspects of PSA.