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白介素6是一个多效细胞因子,它在免疫反应、炎症及造血中发挥重要作用,尚可调节多种细胞的增殖和分化。在肝组织中,白介素6能促进肝细胞的再生,在炎症时调节几种急性时相蛋白的表达而产生急性时相反应。白介素6与肝细胞肝癌的发生、发展有着重要联系。在肝细胞肝癌患者血清中,白介素6水平显著升高。因此,白介素6有望作为肝细胞肝癌的一个新的重要的肿瘤标志物。
Interleukin-6 is a pleiotropic cytokine that plays an important role in immune responses, inflammation, and hematopoiesis. It can also regulate the proliferation and differentiation of many types of cells. In liver tissue, interleukin 6 promotes the regeneration of hepatocytes and regulates the expression of several acute phase proteins during inflammation to produce an acute phase response. Interleukin-6 has an important relationship with the occurrence and development of hepatocellular carcinoma. In serum of patients with hepatocellular carcinoma, interleukin 6 levels were significantly elevated. Therefore, interleukin 6 is expected as a new important tumor marker for hepatocellular carcinoma.