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目的:评价稳心颗粒治疗冠心病合并室性心律失常的临床疗效及安全性。方法:选择冠心病合并室性心律失常患者116例,随机分为对照组和治疗组各58例。在常规治疗基础上,停用目前服用的抗心律失常药物1周,对照组给予胺碘酮口服,每次200mg,每日3次,1周后逐渐减量至维持量每次200mg,每日1次;治疗组在对照组的治疗方案基础上加用稳心颗粒口服,每次9g,每日3次。两组均以4周为1疗程,比较两组病人在治疗前后临床症状,室性早搏或室速次数及不良反应情况。结果:治疗组总有效率91.4%;对照组总有效率72.4%。两组比较有显著差异(p<0.05)。而在不良反应方面两组无显著差异。结论:稳心颗粒治疗冠心病合并室性心律失常有较好的疗效和安全性。
Objective: To evaluate the clinical efficacy and safety of Wenxin Granule in treating coronary heart disease complicated with ventricular arrhythmia. Methods: A total of 116 patients with coronary heart disease and ventricular arrhythmia were randomly divided into control group and treatment group, 58 cases each. On the basis of routine treatment, the current anti-arrhythmic drugs were discontinued for 1 week. The control group was orally administered with amiodarone 200 mg twice daily for 1 week and then gradually reduced to the maintenance dose of 200 mg daily 1 times; treatment group in the control group based on the treatment program plus Wenxin particles oral, each 9g, 3 times a day. Both groups were treated with 4 weeks as a course of treatment. The clinical symptoms, premature ventricular contractions or ventricular tachycardia and adverse reactions were compared between the two groups before and after treatment. Results: The total effective rate was 91.4% in the treatment group and 72.4% in the control group. There was significant difference between the two groups (p <0.05). There was no significant difference in adverse reactions between the two groups. Conclusion: Wenxin Granule has good curative effect and safety in treating coronary heart disease complicated with ventricular arrhythmia.