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目的探究水囊联合不同剂量雌激素辅助治疗宫腔镜术后宫腔粘连的疗效、1年妊娠率及预后效果。方法采用回顾性分析的方法,对2014年10月-2016年10月在惠州市第二妇幼保健院接受治疗的60例宫腔镜术后宫腔粘连患者的临床资料进行分析,根据术后雌激素给药剂量的不同将患者分为低剂量组(4 mg/d,30例)和高剂量组(12 mg/d,30例),并对两组患者的临床治疗效果、1年妊娠率及预后情况进行综合评价。结果高剂量组患者治疗总有效率高于低剂量组,差异有统计学意义(P<0.05)。高剂量组患者1年妊娠率略高于低剂量组,但差异无统计学意义(P>0.05)。治疗前,两组患者子宫内膜厚度比较,差异无统计学意义(P>0.05);经过不同方式的治疗,高剂量组患者子宫内膜厚度显著高于低剂量组,差异有统计学意义(P<0.05)。结论对宫腔镜术后宫腔粘连患者给予水囊联合高剂量雌激素辅助治疗,对再次妊娠无明显影响,可有效改善宫腔镜术后宫腔粘连,促进子宫内膜恢复。
Objective To investigate the curative effect, 1-year pregnancy rate and prognosis of water sac combined with different doses of estrogen in the treatment of uterine adhesions after hysteroscopy. Methods A retrospective analysis of the clinical data of 60 cases of hysteroscopic uterine adhesions treated in Huizhou Second Maternal and Child Health Hospital from October 2014 to October 2016 were analyzed. According to the postoperative female Hormone administration of different doses of patients divided into low-dose group (4 mg / d, 30 cases) and high-dose group (12 mg / d, 30 cases), and the clinical efficacy of two groups of patients, 1 year pregnancy rate And prognosis of a comprehensive evaluation. Results The total effective rate of high-dose group was higher than that of low-dose group, the difference was statistically significant (P <0.05). The 1-year pregnancy rate of high-dose group was slightly higher than that of low-dose group, but the difference was not statistically significant (P> 0.05). Before treatment, there was no significant difference in endometrial thickness between the two groups (P> 0.05). After different treatments, the endometrial thickness in the high-dose group was significantly higher than that in the low-dose group (P <0.05) P <0.05). Conclusion Hysteroscopic hysterectomy in patients with intrauterine adhesions with high dose of estrogen adjuvant treatment of water capsules, no effect on the second pregnancy, which can effectively improve the hysteroscopic adhesions and promote endometrial recovery.