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目的探讨妊娠期高血压疾病孕妇血清钙(Ca)、磷(P)代谢的改变及其临床意义。方法选取宁波市妇女儿童医院2013年6月-12月收治的62例中重度妊娠期高血压疾病孕妇作为观察组。随机选取同期的62例正常孕妇作为对照组。采用生化仪或化学发光仪测定并比较2组孕妇的血清Ca、P、25羟维生素D3[25(OH)D3]、碱性磷酸酶(AKP)、甲状旁腺素(PTH)、降钙素(CT)、骨钙素(BGP)、总胆固醇(CHOL)及甘油三酯(TG)的含量。结果 2组孕妇在Ca、P、AKP、PTH、CT、25(OH)D3、BGP、TG、CHOL上差异均有统计学意义(t值分别为1.98、1.82、2.62、2.02、2.23、2.02、2.23、1.85和2.13,P<0.05)。Logistic回归分析各生化指标对是否有高血压的影响差异均有统计学意义(OR值分别为0.084、0.860、1.083、0.548、1.220、1.203、0.922、1.109和1.006,P<0.05)。其中,PTH、P、CHOL、AKP、TG对是否有高血压的影响为正向,CT、Ca、25(OH)D3对是否有高血压的影响为负向。结论血清Ca、P、25(OH)D3等指标可作为孕妇妊娠期高血压疾病的观察指标,具有重要的意义。
Objective To investigate the changes of serum calcium (Ca) and phosphorus (P) metabolism in pregnant women with gestational hypertension and its clinical significance. Methods Totally 62 pregnant women with moderate and severe gestational hypertension admitted to Ningbo Women and Children Hospital from June to December in 2013 were selected as the observation group. 62 normal pregnant women of the same period were randomly selected as the control group. The levels of Ca, P, 25 hydroxyvitamin D3 [25 (OH) D3], alkaline phosphatase (AKP), parathyroid hormone (PTH), calcitonin (CT), osteocalcin (BGP), total cholesterol (CHOL) and triglyceride (TG). Results There were significant differences in Ca, P, AKP, PTH, CT, 25 (OH) D3, BGP, TG and CHOL between two groups of pregnant women (t values were 1.98,1.82,2.62,2.02,2.23,2.02, 2.23, 1.85 and 2.13, P <0.05). Logistic regression analysis of the biochemical indicators of whether the impact of hypertension have significant differences (OR values were 0.084,0.860,1.083,0.548,1.220,1.203,0.922,1.109 and 1.006, P <0.05). Among them, PTH, P, CHOL, AKP, TG had a positive impact on whether there is hypertension, CT, Ca, 25 (OH) D3 on whether the impact of hypertension is negative. Conclusion Serum Ca, P, 25 (OH) D3 and other indicators can be used as indicators of pregnancy induced hypertension in pregnant women, is of great significance.