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目的研究职业接触铅与女工发生自然流产之间的关系。方法运用计算机和手工检索收集1991至2007年国内发表的关于职业性铅暴露与女工生殖功能关系的文献,经严格筛选后,应用Rev man4.2软件对入选文献的研究结果进行一致性检验并采用相应的数学模型进行数据合并,采用Meta分析合并RR值作为各项目的总效应指标。结果纳入14篇文献(暴露组4 330人,对照组11 970人),与对照组比较,职业性铅暴露与女工发生自然流产(RR=2.83,95%CI:1.97~4.07)的相关有显著的统计学意义(P<0.000 01)。结论我国职业性铅暴露可增加女工自然流产的发生概率。
Objective To study the relationship between occupational exposure to lead and spontaneous abortion of female workers. Methods Using computer and manual retrieval, the literatures published in China from 1991 to 2007 on the relationship between occupational lead exposure and female reproductive function were collected. After rigorous screening, the results of the selected literature were verified by Rev man 4.2 software and adopted The corresponding mathematical model for data consolidation, the use of meta-analysis combined with RR as the total effect indicators of each project. Results There were 14 articles (4 330 in the exposed group and 11 970 in the control group). There was a significant correlation between occupational lead exposure and female spontaneous abortion (RR = 2.83, 95% CI: 1.97-4.07) compared with the control group The statistical significance (P <0.000 01). Conclusion Occupational lead exposure in China may increase the incidence of spontaneous abortion among female workers.