We investigate the effects of the Casimir force on the output properties of a hybrid optomechanical system. In this system, a nanosphere is fixed on the movable-mirror side of the standard optomechanical system, and the nanosphere interacts with the movable-mirror via the Casimir force, which depends on the mirror–sphere separation. In the presence of the probe and control fields, we analyze the transmission coefficient and the group delay of the field-component with the frequency of the probe field. We also study the transmission intensity of the field-component with the frequency of a newly generated four-wave mixing (FWM) field. By manipulating the Casimir force, we find that a tunable slow light can be realized for the field-component with the frequency of the probe field, and the intensity spectrum of the FWM field can be enhanced and shifted effectively.